How do seeds perform against each other, round by round? The following table provides such information over the past 36 tournaments (1985 through 2021, with no tournament in 2020). All seeds match-ups are included in both the Rounds of 64 and 32. Only those seed match-ups that occurred four or more times are included in the remaining rounds. For the Final Four and National Championship games, if the same seeds played each other, only the number of times this occurred is reported.
| Round | Seed Match Up | Record | Round of 64 | 1-16 | 143-1 |
|---|---|---|
| Round of 64 | 2-15 | 135-9 |
| Round of 64 | 3-14 | 122-22 |
| Round of 64 | 4-13 | 113-31 |
| Round of 64 | 5-12 | 93-51 |
| Round of 64 | 6-11 | 90-54 |
| Round of 64 | 7-10 | 87-57 |
| Round of 64 | 8-9 | 71-73 |
| Round of 32 | 1-8 | 57-14 |
| Round of 32 | 1-9 | 66-6 |
| Round of 32 | 2-7 | 57-26 |
| Round of 32 | 2-10 | 34-18 |
| Round of 32 | 3-6 | 45-29 |
| Round of 32 | 3-11 | 30-18 |
| Round of 32 | 4-5 | 41-33 |
| Round of 32 | 4-12 | 26-13 |
| Round of 32 | 5-13 | 16-3 |
| Round of 32 | 6-14 | 14-2 |
| Round of 32 | 7-15 | 2-2 |
| Round of 32 | 10-15 | 5-0 |
| Round of 32 | 11-14 | 6-0 |
| Round of 32 | 12-13 | 9-3 |
| Sweet Sixteen | 1-4 | 40-15 |
| Sweet Sixteen | 1-5 | 36-8 |
| Sweet Sixteen | 1-12 | 20-0 |
| Sweet Sixteen | 1-13 | 4-0 |
| Sweet Sixteen | 2-3 | 28-15 |
| Sweet Sixteen | 2-6 | 25-6 |
| Sweet Sixteen | 2-11 | 14-3 |
| Sweet Sixteen | 3-7 | 9-6 |
| Sweet Sixteen | 3-10 | 9-4 |
| Sweet Sixteen | 4-8 | 4-5 |
| Sweet Sixteen | 6-7 | 5-3 |
| Elite Eight | 1-2 | 23-24 |
| Elite Eight | 1-3 | 16-10 |
| Elite Eight | 1-6 | 8-2 |
| Elite Eight | 1-7 | 4-0 |
| Elite Eight | 1-10 | 4-1 |
| Elite Eight | 1-11 | 4-4 |
| Elite Eight | 2-4 | 2-4 |
| Elite Eight | 2-8 | 2-3 |
| Elite Eight | 3-4 | 2-3 |
| Elite Eight | 4-7 | 2-3 |
| Final Four | 1-1 | 13 |
| Final Four | 1-2 | 7-4 |
| Final Four | 1-3 | 3-4 |
| Final Four | 1-4 | 5-1 |
| Final Four | 2-2 | 3 |
| Final Four | 2-3 | 3-3 |
| National Championship | 1-1 | 8 |
| National Championship | 1-2 | 6-2 |
| National Championship | 2-3 | 3-2 |
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